Invited talks: Formulation issues for biotech drugs

09:00-09:40 Pellet freeze-drying of biopharmaceuticals
Stefan Schneid, Bayer, Wuppertal, Germany
09:40-10:20 L-arginine-based protein formulations in freeze drying: opportunities and challenges
Henning Gieseler, Department of Chemistry and Pharmacy, University Erlangen-Nürnberg, Germany
10:20-11:00 Biologics drug product development: challenges at the interface of formulation, primary packaging and application
Susanne Joerg, Lonza Pharma & Biotech, Verviers, Belgium

Invited talks: Oral drug delivery

09:00-09:40 Hydrophobic ion pairs: a game-changing approach for delivery of BCS class 3 drugs
Andreas Bernkop-Schnürch, Faculty of Chemistry and Pharmacy, University of Innsbruck, Austria
09:40-10:20 Biological barriers to oral delivery of macromolecules
Caitriona O‘Driscoll, School of Pharmacy, University of Cork, Ireland
10:20-11:00 The virtual patient and the in-silico design of solid dosage forms
Hans Leuenberger, College of Pharmcy, University of Florida, Lake Nona medical campus, Orlando, FL, USA

Short talks: Nanotechnology

09:00-09:20 Heterotelechelic polymer prodrug nanoparticles for imaging and combination theraphy
Julien Nicolas, University Paris-Sud, France
09:20-09:40 Enhanced performance of lipid nanocapsule formulations of NIR-emitting conjugated polymers for optical and photoacoustic imaging
Paola Modicano, University of Halle-Wittenberg, Germany
09:40-10:00 Antiangiogenic folate-targeted nanoparticles for docetaxel delivery in ovarian cancer
Claudia Conte, University of Naples Federico II, Italy
10:00-10:20 Cellular and subcellular targeting of TRAP1 as a new therapeutic approach for cancer treatment
Clelia Mathieu, Institute Galien - Paris Sud, France
10:20-10:40 Effects of cytokines release in tissue regeneration and cancer treatments
Slivia Pisani, University of Pavia, Italy
10:40-11:00 Bacterial membrane vesicles as novel treatment avenue for intracellular infections
Adriely Goes, HIPS, Saarbrücken, Germany

Short talks: Continuous manufacturing / Modeling and simulation

09:00-09:20 In-line measurement of granual size distribution in a continuous manufacturing line
Annika Wilms, University of Duesseldorf, Germany
09:20-09:40 Coninuous production of cyclodextrin-based reconstitution powder from aqueous solution using scaled-up electrospinning
Panna Vass, Budapest University of Technology and Economics, Hungary
09:40-10:00 An in-silico workflow for designing a continuous mixing process with DEM simulations
Peter Toson, RCPE, Graz, Austria
10:00-10:20 Visualization of solvent effects on crystal surfaces by chemical force mapping - a combined experimental and simulation approach
Mikkel Herzberg, University of Copenhagen, Denmark
10:20-10:40 Predicting crystal breakage in pharmaceutical agitated dryers
Francois Hallac, University of Leeds, UK
10:40-11:00 CFD modeling on the hydrodynamics in the flow-through dissolution apparatus (UPS 4)
Pracha Bunyawanichakul, Srinakharinwirot University, Nakhonnayok, Thailand

APV award session

11:30-12:00 to be announced
To be determined in March 2020

Plenary lecture

Invited talk

12:00-13:00 Pharmacomicrobiomics: drugs meet the human microbiome
Christine Moissl-Eichinger, Medical University of Graz, Austria

Invited talks: Localised drug delivery

15:00-15:40 Jumping to the brain: Tailored nanomedicines
Giovanni Tosi, University of Modena and Reggio Emilia, Italy
15:40-16:20 Drug delivery to the eye and ear
Amélie Bochot, School of Pharmacy, Institut Galien Paris-Sud, University of Paris Sud/Paris-Saclay, Châtenay-Malabry, France
16:20-17:00 Inhaled chemotherapy: A new modality for lung cancer treatment?
Nathalie Wauthoz, Université Libre de Bruxelles, Belgium

Invited talks: Amorphous drug delivery systems

15:00-15:40 ASDs title tbd
David Lyon, Lonza, USA
15:40-16:20 Hybrid mixtures: A perspective on amorphous solid dispersions in food applications
Lennart Fries, Nestlé Research Center, Vevey, Switzerland
16:20-17:00 The variability of the amorphous state in relation to processing
Marc Descamps, University of Lille, France

Short talks: 2D- and 3D-printing

15:00-15:20 Direct powder extrusion 3D-printing: novel technology for manufacturing amorphous solid dispersions
Alvaro Goyanes, FabRx, London, UK
15:20-15:40 Semi-solid extrusion and 3D-printing: successful duo for the production of personalized gastro-retentive formulations
Marilena Saviano, University of Salerno, Fisciano, Italy
15:40-16:00 Suitability of copovidone for selective laser sintering of pharmaceutical oral dosage forms
Yanis Abdelhamid Gueche, University of Montpellier, France
16:00-16:20 Direct-ink writing of implantable hybrid PCL/PEO drug delivery systems
Se Hun Chung, University College London, UK
16:20-16:40 Investigations on inkjet printed metoprolol tartrate orodispersible films for paediatric application
Olga Kiefer, University of Düsseldorf, Germany
16:40-17:00 Traceable personalized oral dosage forms containing cannabinoids
Heidi Öblom, Abo Akademi University, Finland

Short talks: Transdermal delivery / Protein formulations

15:00-15:20 A new approach to predict in vitro-in vivo correlation for transdermal therapeutic systems
Dorothea Gutekunst, LTS Lohmann Therapie-Systeme, Andernach, Germany
15:20-15:40 mRNA based skin vaccination by intradermal applications of lipid coated polymeric nanoparticles
Lena Kliesch, HIPS, Saarbrücken, Germany
15:40-16:00 Targeted iontophoretic delivery of an anti-EGFR monoclonal antibody to skin
Maria Lepteva, University of Geneva, Switzerland
16:00-16:20 A multi-method approach to assess self-interaction behaviour on infliximab as a model protein
Martin Domnowski, LMU Munich, Germany
16:20-16:40 Continuous alternative to freeze-drying: solid formulation of a monoclonal antibody using high-speed electrospinning
Júlia Domján, Budapest University of Technology and Economics, Hungary
16:40-17:00 A holistic approach to develop a spray-drying method for CXCL8
Sonja Hartl, RCPE, Graz, Austria