Invited talks: In silico simulation for manufacturing processes

09:00-09:40 Digitalization in pharmaceutical product and process design: from advanced simulations to virtual drug product development
Johannes Khinast, Graz University of Technology, Austria
09:40-10:20 Digital Process Design
Sean Bermingham, Process System Enterprise (PSE), London, United Kingdom
10:20-11:00 Modelling and simulation of fluid-bed processes
Stefan Heinrich, Hamburg University of Technology, Germany

Invited talks: Nanofabrication technologies

09:00-09:40 Novel manufacturing for healthcare: microbubbles, particles, capsules and fibres
Mohan Edirisinghe, Biomaterials Processing Laboratory, Department Mechanical Engineering, University College London, United Kingdom
09:40-10:20 Advances in electrospinning
Nalin de Silva, Department of Chemistry, University of Colombo, Sri Lanka
10:20-11:00 Advanced in vitro lung-on-chip platforms for inhalation assays
Josue Sznitman, Department of Biomedical Engineering, Israel Institute of Technology, Haifa, Israel

Short talks: Processing and PAT

09:00-09:20 Physical and chemical concerns for cryomilling as manufacturing technique to produce amourphous solid dispersions: effect on APIs and carriers
Timothy Pas, KU Leuven, Belgium
09:20-09:40 Production and downstream-processing of API-nanosuspensions
Arno Kwade, Technical University of Braunschweig, Germany
09:40-10:00 Improving particle size distributions in a conical mill through new impeller air flow optimization comparisons utilizing computational fluid dynamics (CFD) analysis and empirical DoE
Wilf Sanguesa, Quadro Engineering, Ontario, Canada
10:00-10:20 Process control of high shear melt granulation processes by inline particle size analysis
Dominic Kamke, OWL University of Applied Sciences and Arts, Detmold, Germany
10:20-10:40 Designing an at-line PAT tool - a fluid bed coating case study
Jaspreet Arora, Lonza Pharma and Biotech, Bend, USA
10:40-11:00 NIR as an in-line PAT tool to study desorption kinetics in spin freeze-dried formulations
Laurens Leys, Ghent University, Belgium

Short talks: Gene delivery and ATMP

09:00-09:20 Formulation development to stabilize viral vectors
Eva Reinauer, Leukocare, Munich, Germany
09:20-09:40 Delivery of RNA in vivo using SS-cleavable and pH-responsive lipid-like materials
Daniel Zucker, NOF Europe , Frankfurt, Germany
09:40-10:00 Anti-EGFR nanovector of siRNA - a theranostic tool for triple negative breast cancer active targeting
Phuoc Vinh Nguyen, Tours University, France
10:00-10:20 siRNA in lung slices: knocking down fibrosis?
Mitchel Ruigrok, University of Groningen, The Netherlands
10:20-10:40 Lyophilization of human cells in presence of DMSO
Ute Rockinger, LMU Munich, Germany
10:40-11:00 MSC extracellular vesicles for treatment of alpha-1-antitrypsin deficiency pulmonary diseases
Elia Bari, University of Pavia, Italy

ADRITELF award session

11:30-12:00 International ADRITELF Award 2020 Maria Edvige Sangalli
To be determined in March 2020

Plenary lecture

Invited talk

12:00-13:00 Oral drug delivery systems: from irrelevance to top-selling products and ongoing challenges
Andrea Gazzaniga, Biopharmaceuticals and Pharmaceutical Technology Laboratory, University of Milan, Italy

Invited talks: Dermal and transdermal delivery

15:00-15:40 Skin permeation from pickering emulsions
Marie-Alexandrine Bolzinger, Claude Bernard University Lyon, France
15:40-16:20 Microarray patches for high-dose drug delivery: targeting global healthcare challenges
Ryan F. Donnelly, School of Pharmacy, Queen's University Belfast, United Kingdom
16:20-17:00 Improved vaccine immunogenicity through microneedle delivery
Michael Schrader, Vaxess, Boston, MA, USA

Invited talks: Continuous manufacturing

15:00-15:40 Process development of the future: fully automated DoE process analysis in an integrated continuous manufacturing plant for solid oral dosage forms
Victoria Pauli, Novartis, Basel, Switzerland
15:40-16:20 Pfizer´s "continuous" journey - Implementing continuous manufacturing into a factory for solid dosage forms
Clemens Stief, Pfizer, Freiburg, Germany
16:20-17:00 Continuous manufacturing of solid dosage forms; opportunities and controversies
Kendal Pitt, GlaxoSmithKline, Ware, United Kingdom

Short talks: Advanced drug delivery

15:00-15:20 Repurposing of cationic amphiphiles to promote cytosolic RNA delivery
Koen Raemdonck, Ghent University, Belgium
15:20-15:40 Antibody-functionalised electrosprayed microparticles for in-vivo T-cell activation
Karolina Dziemidowicz, University College London, UK
15:40-16:00 Intravitreal administration of bevacizumab: optimization of freeze-dried solid matrices
Eleonora Terreni, University of Pisa, Italy
16:00-16:20 FRET as a tool for monitoring polyplex assembly and for tracking its cellular fate
Lorenz Isert, LMU Munich, Germany
16:20-16:40 A novel polyethlyene glycol-based linker platform for the development of hydrophilic antibody-drug conjugates
Gianfranco Pasut, University of Padova, Italy
16:40-17:00 Microspheres with ultrahigh mass fraction of therapeutics inspired by pomegranate
Wei Li, University of Helsinki, Finland

Short talks: Oral drug delivery / Pediatric formulations

15:00-15:20 Poly(ethylene oxide)-block-Poly(ε-Caprolactone) micelles for oral delivery of Cyclosporine A: a tissue distribution study
Ziyad Binkhathlan, King Saud University, Riyadh, Saudi Arabia
15:20-15:40 X-ray imaging of micorcontainers used for oral drug delivery
Rolf B. Kjeldsen, Technical Univeristy of Denmark, Lyngby, Denmark
15:40-16:00 Controlled permeability enhancement with short peptide inhibitors of protein kinase C zeta
Joel Brunner, University of Geneva, Switzerland
16:00-16:20 A toolbox for mimicking gastrointestinal conditions in children: S(imulated) P(ediatric) B(reakfast) M(edia) for addressing the variability of gastric contents after typical paediatric breakfasts
Lisa Freerks, University of Greifswald, Germany
16:20-16:40 Design and evaluation of self-emulsifying drug delivery system for pediatric use
Xiaona Liu, University of Copenhagen, Denmark
16:40-17:00 Acceptability of antibiotics in pediatrics: findings from an international observational study
Thibault Vallet, ClinSearch, Malakoff, France