Invited talks incl. Q&A: In silico simulation for manufacturing processes

08:45-09:35 Digitalization in pharmaceutical product and process design: from advanced simulations to virtual drug product development
Johannes Khinast, Graz University of Technology, Austria
09:35-10:25 Digital Process Design
Sean Bermingham, Process System Enterprise (PSE), London, United Kingdom
10:25-10:40 Study of the drying process in simulated pharmaceutical coatings: Model and experiment
Ondrej Navratil, University of Prague, Czech Republic
10:40-10:55 to be determind
to be determind
10:55-11:15 Question and answer session

Invited talks incl. Q&A: Nanofabrication technologies

08:45-09:35 Novel manufacturing for healthcare: microbubbles, particles, capsules and fibres
Mohan Edirisinghe, Biomaterials Processing Laboratory, Department Mechanical Engineering, University College London, United Kingdom
09:35-10:25 Advances in electrospinning
Nalin de Silva, Department of Chemistry, University of Colombo, Sri Lanka
10:25-11:15 Advanced in vitro lung-on-chip platforms for inhalation assays
Josue Sznitman, Department of Biomedical Engineering, Israel Institute of Technology, Haifa, Israel

Short talks: Gene delivery and ATMP

08:45-09:00 Formulation development to stabilize viral vectors
Sabine Hauck, Leukocare, Munich, Germany
09:00-09:15 Tablets of siRNA lipoplexes: impact of processes on structure and gene-silencing efficacy
Virgine Busignies, University of Bordeaux, France
09:15-09:35 Question and answer session
09:35-09:50 Anti-EGFR nanovector of siRNA - a theranostic tool for triple negative breast cancer active targeting
Phuoc Vinh Nguyen, Tours University, France
09:50-10:05 siRNA in lung slices: knocking down fibrosis?
Mitchel Ruigrok, University of Groningen, The Netherlands
10:05-10:25 Question and answer session
10:25-10:40 mRNA based Skin Vaccination by intradermal application of lipid coated polymeric nanoparticles
Lena Kliesch, Helmholtz-Institute for Pharmaceutical Research Saarland, Germany
10:40-10:55 MSC extracellular vesicles for treatment of alpha-1-antitrypsin deficiency pulmonary diseases
Elia Bari, University of Pavia, Italy
10:55-11:15 Question and answer session

Short talks: Advanced drug delivery

08:45-09:00 Repurposing of cationic amphiphiles to promote cytosolic RNA delivery
Koen Raemdonck, Ghent University, Belgium
09:00-09:15 Alginate-spermidine microgels as filling matrix of multi-channel PLGA scaffolds for the treatment of peripheral nerve injuries
Caterina Valentino, University of Pavia, Italy
09:15-09:35 Question and answer session
09:35-09:50 Preparation and evaluation of anticancer agent nanocrystals
Yohann Corvis, University of Paris, France
09:50-10:05 Evaluation of in vivo efficacy of ferrocifen loaded lipid nanocapsules on ovarian cancer
Elise Lepeltier, University of Angers, France
10:05-10:25 Question and answer session
10:25-10:40 A novel polyethlyene glycol-based linker platform for the development of hydrophilic antibody-drug conjugates
Tommaso Tedeschini, University of Padova, Italy
10:40-10:55 Dithiolane-crosslinked polymer micelles: reduction responsive drug release
Cornelus van Nostrum, University of Utrecht, The Netherlands
10:55-11:15 Question and answer session

ADRITELF award session

11:45-12:15 International ADRITELF Award 2020
Giuseppe De Rosa, University of Naples Federico II, Italy

Plenary lecture incl. Q&A

Invited talk

12:15-13:15 Oral drug delivery systems: from irrelevance to top-selling products and ongoing challenges
Andrea Gazzaniga, Biopharmaceuticals and Pharmaceutical Technology Laboratory, University of Milan, Italy

Invited talks incl. Q&A: Dermal and transdermal delivery

14:45-15:35 Skin permeation from pickering emulsions
Marie-Alexandrine Bolzinger, Claude Bernard University Lyon, France
15:35-16:25 Microarray patches for high-dose drug delivery: targeting global healthcare challenges
Ryan F. Donnelly, School of Pharmacy, Queen's University Belfast, United Kingdom
16:25-17:15 Improved vaccine immunogenicity through microneedle delivery
Michael Schrader, Vaxess, Boston, MA, USA

Invited talks incl. Q&A: Continuous manufacturing

14:45-15:35 Process development of the future: fully automated DoE process analysis in an integrated continuous manufacturing plant for solid oral dosage forms
Victoria Pauli, Novartis, Basel, Switzerland
15:35-16:25 To be determind
to be determind
16:25-17:15 Continuous manufacturing of solid dosage forms; opportunities and controversies
Kendal Pitt, GlaxoSmithKline, Ware, United Kingdom

Short talks: Oral drug delivery / Pediatric formulations

14:45-15:00 The Use of Partially Hydrolysed Polyvinyl Alcohol for The Production of High Drug-Loaded Sustained Release Pellets via Extrusion-Spheronization and Coating: In Vitro and In Vivo Evaluation
Valerie Vanhoome, University of Ghent, Belgium
15:00-15:15 X-ray imaging of micorcontainers used for oral drug delivery
Rolf B. Kjeldsen, Technical Univeristy of Denmark, Lyngby, Denmark
15:15-15:35 Question and answer session
15:35-15:50 Controlled permeability enhancement with short peptide inhibitors of protein kinase C zeta
Joel Brunner, University of Geneva, Switzerland
15:50-16:05 A toolbox for mimicking gastrointestinal conditions in children: S(imulated) P(ediatric) B(reakfast) M(edia) for addressing the variability of gastric contents after typical paediatric breakfasts
Lisa Freerks, University of Greifswald, Germany
16:05-16:25 Question and answer session
16:25-16:40 Design and evaluation of self-emulsifying drug delivery system for pediatric use
Xiaona Liu, University of Copenhagen, Denmark
16:40-16:55 Acceptability of antibiotics in pediatrics: findings from an international observational study
Thibault Vallet, ClinSearch, Malakoff, France
16:55-17:15 Question and answer session

Short talks: Processing and PAT

14:45-15:00 Improving flowability and reducing storage agglomeration of metformin hydrochloride through QESD crystallization
Jerome Hansen, University of D├╝sseldorf, Germany
15:00-15:15 Production and downstream-processing of API-nanosuspensions
Arno Kwade, Technical University of Braunschweig, Germany
15:15-15:35 Question and answer session
15:35-15:50 Improving particle size distributions in a conical mill through new impeller air flow optimization comparisons utilizing computational fluid dynamics (CFD) analysis and empirical DoE
Wilf Sanguesa, Quadro Engineering, Ontario, Canada
15:50-16:05 Innovative preparation of API salt coated on particles using fluidised bed
Jakub Muzik, University of Prague, Czech Republik
16:05-16:25 Question and answer session
16:25-16:40 Insight into the impact of compaction process variations on tablet disintegration by non-destructive at-line terahertz porosity sensing
Prince Bawuah, University of Cambridge, United Kingdom
16:40-16:55 NIR as an in-line PAT tool to study desorption kinetics in spin freeze-dried formulations
Laurens Leys, Ghent University, Belgium
16:55-17:15 Question and answer session